DIT aims to exploit the photolithography process to fabricate microfluidic biosensor devices using photocurable sol-gel materials. The investigators have developed the materials and processes since early work published in 2005.
The process employs low cost sol-gel materials and the photolithography process, widely used in the semi-conductor industry. This versatile technology enables fabrication of extremely fine microchannels with high resolution. Straight channels and complex serpentine channel patterns are possible (Figure 1).
The sol-gel materials may be modified or surfacefunctionalised to increase hydrophilicity, promoting rapid liquid flow throughout the microfluidic devices. Other microfluidic structures such as micropillars may be fabricated, to promote fluid flow via capillary wicking.
Sol-gel chemistry is compatible with a wide range of biosensing mechanisms. Hydrophobic drugs, metabolites and other reagents may be absorbed into the device’s material. A recent proof-ofconcept study by the investigators fabricated a device with multiple sensor spots.
Dublin Institute of Technology
Dr. Mohamed Oubaha Mohamed,
Ms. Mary O’ Sullivan,
Dr. Brendan Duffy.